ACL Reconstruction Triples 20-Year Risk of Total Knee Arthroplasty
A study of 135,881 patients shows a 2.44% absolute risk of knee replacement two decades after surgery, rising with meniscal involvement.
Redlining and Modern Loan Denials Drive Chicago Firearm Homicides
Historical housing maps and current economic discrimination act as independent, measurable factors in urban firearm violence disparities.
Adipose Blocks Stored at -80 °C Maintain Multipotent Cell Viability
A protocol using commercial freezers and rapid thawing preserves 88% of stromal vascular fraction cells for up to four months.
CSF Tau Biomarkers Associate With Cognitive Impairment in ALS
Elevated cerebrospinal fluid tau levels correlate with cognitive deficits in ALS, though postmortem TDP-43 burden remains a stronger driver.
Dihydroartemisinin-Piperaquine Reduces Early Plasmodium vivax Recurrence Compared With Chloroquine
A randomized trial in Brazil shows dihydroartemisinin-piperaquine effectively prevents early malaria recurrence when primaquine is delayed.
Validated 33-Item Instrument Quantifies Patient Misconceptions Regarding Hospice Care
The Hospice Perceptions Instrument identifies specific barriers to enrollment, including myths about eligibility and service quality.
Early Cystography After Bladder Repair Reduces Catheter Time and Infections
Imaging within seven days of traumatic bladder repair safely shortens catheterization and lowers infection rates without missing leaks.
Dementia With Lewy Bodies Incidence Rises Sharply After Age 65
A meta-analysis of population-based studies reveals significant age and sex disparities in dementia with Lewy bodies epidemiology.
Single Sigmoidoscopy Reduces Male Colorectal Cancer Death at 23 Years
A Norwegian trial shows a single screening sigmoidoscopy provides long-term protection for men, but mortality benefits are absent in women.
Beti-cel Gene Therapy Sustains Transfusion Independence for Up to Ten Years
Long-term data show 90.2% of phase 3 patients achieved transfusion independence with stable hemoglobin and improved iron homeostasis.
Palliative Care Reduces Hospital Death Risk in Multiple Sclerosis
A large cohort study finds neurology oversight drops sharply before death, while rural patients face higher hospital mortality rates.
Tenecteplase Before Thrombectomy Does Not Improve Late-Window Stroke Outcomes
A phase 3 trial in patients with proximal MCA occlusions found no functional benefit to adding tenecteplase between 4.5 and 24 hours.