Normative Modeling Maps Individual Brain Deviations in Traumatic Brain Injury
Patient-specific MRI analysis reveals unique structural changes that traditional group-level averages often obscure in moderate-to-severe TBI.
Lower Limb Alignment Shifts Toward Varus a Decade After Knee Replacement
Long-term radiographic follow-up shows significant increases in femoral lateral bowing and mechanical axis deviation 10 years postoperatively.
Behavioral Activation Reduces Pain During Smoking Cessation in Depressed Adults
A secondary analysis finds that behavioral activation therapy significantly lowers bodily pain scores compared to standard cessation care.
Sympathy Mediates Nursing Care Tendencies in Alcohol Use Disorder
A cross-sectional study of 348 nurses finds that sympathy, not fear or anger, drives helping behaviors despite perceived patient stigma.
Early IL-6 Levels Predict Sepsis-Induced Coagulopathy with High Specificity
Day 1 interleukin-6 concentrations above 5,571 pg/mL identify patients at high risk for disseminated intravascular coagulation.
Digital and Primary Care Intervention Reduces Adolescent Depressive Symptoms in Slums
A randomized trial in India shows a multimedia campaign and digital tools improve mental health literacy and lower PHQ-9 scores.
Polygenic Risk Scores Identify High Susceptibility for Eight Cardiovascular Traits
A validated clinical report using data from 298,700 participants quantifies inherited risk for conditions including CAD and hypertension.
Etelcalcetide Reverses Cardiac Dysfunction in Mice with Chronic Hyperphosphatemia
The calcimimetic restores systolic function and reduces fibrosis by directly activating calcium-sensing receptors in the myocardium.
Cognitive Reserve Delays Symptom Onset in Dominantly Inherited Alzheimer Disease
Higher cognitive reserve is associated with a fourfold increase in the odds of remaining asymptomatic despite genetic risk factors.
Iodine Antiseptics Safe for Patients With Documented Iodine Allergy Labels
A prospective study of 1,211 joint replacements shows no allergic reactions to povidone-iodine protocols in patients with allergy labels.
Medically Assisted Reproduction Shows No Independent Link to Perinatal Distress
A prospective cohort study of 9,289 women found that baseline characteristics, not conception mode, drive mental health outcomes.
Prefrontal Hypoactivation and Time Distortion Linked to Adolescent Self-Injury
Adolescents who self-harm show reduced left dorsolateral prefrontal cortex activity and a distinct inability to accurately estimate time.