Individual LPFC Maps Reveal Fine-Grained, Interdigitated Networks
Precision fMRI in 10 individuals shows the lateral prefrontal cortex has a more fragmented and functionally distinct organization than group.
SHANK3 Haploinsufficiency in Macaques Reveals Diverse Behavioral, Cognitive Phenotypes
A new macaque model of SHANK3 haploinsufficiency provides insights into Phelan-McDermid syndrome and potential biomarkers.
Secreted GPNMB Drives Alpha-Synuclein Spread in Parkinson's Disease
A new study identifies a microglial-neuronal feedback loop involving GPNMB that exacerbates alpha-synuclein pathology, offering a therapeutic target.
Prefrontal GABAergic Synaptic Plasticity Regulates Cognitive Flexibility
A new study identifies a specific long-range inhibitory synaptic mechanism in the prefrontal cortex crucial for adapting to changing rules.
GABAergic Signaling and SST Interneurons Boost Dendritic Calcium Influx
A new study in mice reveals how specific GABA-A receptors and somatostatin-expressing interneurons can paradoxically enhance neuronal calcium signalin
Arterial Netrin-4 Maintains Adult Sympathetic Neurons in Mice
Intracranial arteries provide a trophic niche that prevents age-related neuronal attrition through a non-inflammatory death pathway.
Hierarchical Retinal Circuits Enhance Low-Contrast Detection in Mice and Humans
A dual-mode synaptic architecture using glutamate clouds and driver cells improves signal sensitivity beyond independent cell channels.
Locomotion Selectively Suppresses Hippocampal Pyramidal Cell Bursting in Mice
All-optical electrophysiology reveals that balanced excitatory and inhibitory inputs modulate gain in CA1 neurons during physical activity.
Nucleus Accumbens Dopamine Regulates Multi-Option Foraging Rates in Mice
A global learning rate in the nucleus accumbens core allows for rapid value integration across six concurrent choices in large arenas.
Visual Cortex Pathways Form Adult-Like Architecture Before Birth
MRI data from 584 neonates show that dorsal and ventral streams develop at different rates during the third trimester.
Norepinephrine Drives Sleep-Dependent Astrocyte Volume Changes in Mouse Cortex
Astrocyte expansion during wakefulness reduces interstitial space and suppresses glymphatic flow via alpha-1 adrenergic signaling.
Lactate Enzyme Overexpression Enhances Remyelination in Animal Models
Restoring glycolysis and lactate production in oligodendrocyte precursors overcomes epigenetic silencing to stimulate myelin repair.