ClinGen Panel Validates 34 Glomerular Disease Genes for Clinical Use
A new expert review provides a definitive list of genes with robust evidence for their role in glomerular phenotypes, aiding diagnosis and management.
Weight Restoration Reverses Subcortical Limbic Changes in Anorexia Nervosa
Brain volume reductions in AN largely normalize with weight gain, linked to leptin, ghrelin, and neurofilament light changes.
Multimodal Training Improves Pediatric CPR Depth, Rate Compliance in ED
A quality improvement initiative in a pediatric emergency department enhances chest compression metrics through integrated coach and compressor…
Venetoclax Plus Chemotherapy Improves MRD Response, Survival in Ph-Negative ALL
A phase 2 study shows venetoclax combined with pediatric-inspired chemotherapy enhances outcomes for newly diagnosed adolescents and adults.
Pediatric SAKI Subphenotypes Predict Outcomes, Inform Treatment Responses
Distinct subphenotypes of pediatric sepsis-associated acute kidney injury show varying severity, molecular profiles, and responses…
Contextual Fit Drives Physical Activity Program Success in Disadvantaged Schools
A review of 16 interventions identifies key implementation conditions for effective physical activity programs in socio-economically disadvantaged…
Brain Connectivity Predicts Escitalopram Response in Depressed Adolescents
Specific resting-state functional connectivity patterns may identify adolescents with major depressive disorder who will respond to escitalopram.
Consensus Checklist and Passing Standard for Brain Death Competency
A Delphi and Angoff process established a 98-item checklist and an 89% minimum passing score for BD/DNC determination.
Germline Variants Linked to Increased Cancer Risk in Pediatric Patients
A large-scale analysis of pediatric exome sequencing data reveals specific germline variants significantly elevate future cancer incidence.
Brain-Wide Index Identifies Youth at Risk for Bipolar Disorder
A new study links a structural brain marker, the Regional Vulnerability Index for Bipolar Disorder, to familial risk and early symptoms.
Population Screening Identifies Early Type 1 Diabetes in Children, Quantifies Progression
A large-scale study in Bavaria, Germany, reveals the prevalence and progression rates of presymptomatic type 1 diabetes in a general pediatric…
EPAC2 Antagonism Restores Cortical Function, Behavior in Fragile X Mouse Model
Targeting EPAC2 reverses molecular and functional deficits in a preclinical model of Fragile X Syndrome, suggesting a therapeutic avenue.