Pediatric Fibula Harvest Carries High Risk of Ankle Valgus and Nerve Palsy
A 27-year review identifies the Age-Residual Fibula Index as a key predictor for donor-site morbidity in skeletally immature patients.
Children Witness Nearly Ten Percent of US Violent Deaths and Suicides
A CDC surveillance analysis reveals that most child-witnessed fatal events occur in homes and involve firearms or domestic conflict.
Medicaid Expansion Linked to Lower Mortality in Young Adult Dialysis Patients
A cohort study shows a 1.8 percentage point drop in one-year mortality for young adults starting dialysis after Medicaid expansion.
Beti-cel Gene Therapy Sustains Transfusion Independence for Up to Ten Years
Long-term data show 90.2% of phase 3 patients achieved transfusion independence with stable hemoglobin and improved iron homeostasis.
Nurse-Led School CPR Program Multiplies Community Training Reach
Students using low-cost manikins trained an average of 2.4 family members, significantly expanding the pool of potential bystanders.
POT1 Mutations Drive Lymphoid Malignancy Through Ultralong Telomeres
Pathogenic POT1 variants increase lymphoma risk eightfold by extending cellular longevity and promoting age-dependent clonal expansion.
Quality Improvement Shortens Time to Antibiotics in Pediatric Intestinal Failure
Multidisciplinary interventions reduced median cephalosporin delivery time by 58% for children with suspected central line infections.
Early Chelation Prevents Cardiac Iron Overload in Diamond–Blackfan Anemia
A retrospective study of 64 infants shows that initiating chelation at a median age of 18 months reduces ferritin and protects the heart.
IVC to Aorta Ratio Tracks Fluid Response but Lacks Clinical Correlation
Ultrasound metrics of the inferior vena cava change after fluid boluses in pediatric shock but do not align with heart rate or shock index.
CFTR Modulators Reduce 8-Year Mortality Risk by 7.2% in Cystic Fibrosis
A registry-based cohort study of 25,103 individuals shows a 66% reduction in the hazard of death following modulator initiation.
Child Maltreatment Linked to Systemic Homeostatic Dysregulation
Recent trauma in children may disrupt physiological stability and delay development in males rather than accelerating biological aging.
SSPOP Gene Mutations Linked to Pediatric Epilepsy and Developmental Delay
Researchers identify pathogenic variants in a presumed pseudogene, expanding the diagnostic landscape for unexplained seizure disorders.