Sutureless Robotic Partial Nephrectomy Noninferior to Renorrhaphy for Renal Tumors
A randomized controlled trial indicates sutureless off-clamp robotic partial nephrectomy offers comparable surgical quality for cT1-2N0M0 renal tumors
Telitacicept Reduces Proteinuria in IgA Nephropathy: Phase 3 Interim Analysis
A dual BAFF and APRIL antagonist significantly lowers urinary protein-to-creatinine ratio in adults with IgA nephropathy at high risk of progression.
Brepocitinib 30 mg Improves Dermatomyositis Symptoms and Reduces Glucocorticoid Need
A phase 3 trial shows that once-daily oral brepocitinib 30 mg significantly improves disease activity and allows for glucocorticoid tapering in adults
PsA Improvement Thresholds Vary by Baseline Disease Activity, Not Prior TNFi Exposure
Minimal clinically important improvement (MCII) thresholds in psoriatic arthritis depend on baseline disease severity, guiding personalized treatment.
Teriparatide Plus Zoledronic Acid Does Not Reduce Fracture Risk in Adults with OI
A randomized trial found that while combination therapy increased bone mineral density, it did not lower fracture incidence.
Patient-Level Adherence Drives Enhanced Recovery Benefits in Pediatric GI Surgery
A stepped-wedge trial shows that while site-level ERP implementation may not reduce length of stay, patient-level adherence does.
Lower Oxygen Saturation Target Reduces Pediatric Hospital Stay, Oxygen Therapy
A multicenter trial suggests targeting 88% peripheral oxygen saturation in children with acute respiratory illness shortens hospitalizations.
Acupuncture and Herbal Formula Improve Visual Acuity in Optic Atrophy
Combining acupuncture with Jieyu Huoxue Formula reduces blood viscosity and increases peak systolic velocity to protect the optic nerve.
Tirzepatide Reduces Major Kidney Events More Than Dulaglutide
In patients with type 2 diabetes and cardiovascular disease, tirzepatide lowered the risk of renal outcomes by 23% over four years.
Intra-Arterial Alteplase Improves Recovery After Successful Thrombectomy
Adjunctive thrombolysis increased 90-day functional independence by 15% but was associated with a nearly 6% increase in mortality.
Deucravacitinib Modulates Over 2,500 Genes in Systemic Lupus Erythematosus
Transcriptomic analysis shows TYK2 inhibition reverses myeloid dysregulation and increases regulatory T-cell populations in patients with lupus.
Accelerated Deep TMS Protocols Show High Remission Rates in Depression
A randomized trial finds that 10-day accelerated deep TMS protocols achieve 42% to 50% remission rates, exceeding pharmacotherapy alone.