The Briefing
Continuous newsroom coverage of clinically relevant evidence — newest first.
Earlier
24 stories-
THC Disrupts Rat Fear Memory via Sex-Specific Microglial and Receptor Pathways
In male rats, THC requires microglial recruitment and dual receptor signaling, while female effects depend on the estrous cycle and CB1.
-
Gamma Knife Surgery Provides Durable Control of Vestibular Schwannoma
A 30-year study shows true tumor progression is rare after 10 years, supporting reduced imaging for patients stable at the 5-year mark.
-
Child Maltreatment Linked to Systemic Homeostatic Dysregulation
Recent trauma in children may disrupt physiological stability and delay development in males rather than accelerating biological aging.
-
Propofol Reduces Long-Term Water Contamination Compared to Sevoflurane
A modeling study finds sevoflurane leads to irreversible accumulation of trifluoroacetic acid while propofol residues remain biodegradable.
-
Lumateperone Leads Efficacy While Aripiprazole Shows Best Acceptability in Depression
A meta-analysis of 10,962 patients quantifies the trade-offs between symptom reduction and treatment adherence for adjunctive antipsychotics.
-
BRAF V600E Mutation Predicts Early Recurrence in Rathke Cleft Cysts
A retrospective analysis of 383 sellar lesions suggests BRAF-positive cysts behave like papillary craniopharyngiomas and require reclassification.
-
Sleep Efficiency Improvements Drive Antidepressant Response to CBT for Insomnia
A mechanistic trial shows that objective sleep gains, not changes in brain emotional circuits, correlate with improved mood symptoms.
-
Nucleus Accumbens Dopamine Regulates Multi-Option Foraging Rates in Mice
A global learning rate in the nucleus accumbens core allows for rapid value integration across six concurrent choices in large arenas.
-
Penetrating Brain Injury Mortality Reaches 42% While Prophylaxis Compliance Lags
Despite high mortality, 70% of survivors achieve favorable outcomes, though adherence to antibiotic and seizure protocols remains low.
-
Tirofiban Improves 90-Day Outcomes After Inadequate Tenecteplase Response
Adjunctive tirofiban increased the rate of functional independence in patients with non-large vessel stroke who failed to improve.
-
SMART Model Matches Radiologists in Differentiating New Lung Malignancies
A CT-based tool using semantic features like emphysema and spiculation helps distinguish second primary lung cancers from metastases.
-
Chronic Stroke Survivors Retain Motivational Drive Despite Impaired Reward Learning
A study of 40 patients shows that while stroke slows belief updating, the ability to speed up movements for rewards remains intact.
-
SSPOP Gene Mutations Linked to Pediatric Epilepsy and Developmental Delay
Researchers identify pathogenic variants in a presumed pseudogene, expanding the diagnostic landscape for unexplained seizure disorders.
-
Prostate SBRT Maintains 90% Relapse-Free Survival at Ten Years
A multi-center trial of 310 patients shows low- and intermediate-risk prostate cancer control remains durable with minimal late toxicity.
-
CT Metrics Predict Benralizumab Response in Severe Asthma
Quantitative imaging of small airway disease and sinus opacification identifies responders more accurately than blood eosinophil counts.
-
Magnetic Seizure Therapy Limits Memory Loss in Bipolar Depression Trial
A randomized pilot study shows magnetic seizure therapy matches the efficacy of ultrabrief ECT while reducing cognitive adverse effects.
-
Microsurgical Breast Reconstruction Remains Undervalued Despite Improved Efficiency
A 13-year analysis reveals that while free flap reimbursement per hour has risen, it still lags significantly behind implant-based options.
-
Skin Biopsies Differentiate Body-First and Brain-First Parkinson’s Disease
Cutaneous alpha-synuclein patterns and seeding kinetics identify distinct pathological origins in Parkinson’s disease subtypes.
-
Prefrontal Cortex Origin for Rhythmic Ictal Nonclonic Hand Motions
Intracerebral recordings show that specific hand motions often linked to temporal lobe epilepsy can originate in the middle frontal gyrus.
-
Automated Software Identifies Hundreds of Patients Lost to Aneurysm Follow-Up
Natural language processing of 7.5 million imaging reports captured 492 new patients and generated 47 surgical repairs.
-
Brain FAAH Levels Rise During Short-Term Cannabis Abstinence
PET imaging shows enzyme increases in the ventral striatum correlate with depression and impulsivity during early withdrawal.
-
Perinatal Cash Transfers Linked to 32% Drop in Infant Maltreatment Reports
A study of Flint's Rx Kids program shows unconditional cash support significantly reduces child protective services investigations.
-
Transcortical Mapping for Insular Glioma Limits Deficits and Improves Survival
A 500-case analysis identifies specific residual volume thresholds that correlate with survival while keeping permanent deficits under 4%.
-
Advanced Paternal Age Increases Autism Risk in Grandchildren via Female Lineage
A registry study of 12.6 million people shows that a grandfather's age at his daughter's birth influences his grandchildren's autism risk.