Tau Aggregates Drive Neuronal Death via ZBP1 Activation in Tauopathies
A new study identifies a molecular cascade where tau aggregates reactivate transposable elements, leading to Z-RNA-ZBP1-mediated neuronal death.
Cortical Stimulation Modulates Hippocampal Activity in Temporal Lobe Epilepsy Mouse Model
A mouse model study identifies intensity-specific effects of cortical electrical stimulation on aberrant hippocampal oscillations and action.
Retrosplenial Cortex Adapts History Integration for Flexible Decisions
Mouse study reveals how the retrosplenial cortex dynamically adjusts its processing of past experiences to support adaptive behavior.
Red Blood Cells Contribute Alpha-Synuclein to Parkinson's Brain Pathology
A new study in human tissues and mouse models identifies erythrocytes as a peripheral source of alpha-synuclein, influencing central nervous system.
Ependymal Cilia Mechanics Control Adult Neural Stem Cell Quiescence
A new study identifies how mechanical forces from ependymal cell cilia regulate neural stem cell activity through specific ion channels.
EPAC2 Antagonism Restores Cortical Function, Behavior in Fragile X Mouse Model
Targeting EPAC2 reverses molecular and functional deficits in a preclinical model of Fragile X Syndrome, suggesting a therapeutic avenue.
Micropipette-Guided Administration Delivers Analgesics to Mouse Brains
A less invasive method for administering carprofen and buprenorphine in mice achieves therapeutic brain levels, particularly for buprenorphine.
Melittin Mitigates Doxorubicin-Induced Neurotoxicity in Murine Models
A study in mice suggests melittin, a bee venom component, reduces doxorubicin's neurotoxic effects by targeting inflammation and oxidative stress.
TSPO Deletion Reduces Cortical Spreading Depolarization in Mice
A new study in mice suggests that modulating translocator protein 18 kDa may influence CSD generation and associated neurovascular and inflammatory re
MSK1 Mediates BDNF Signaling in Striatal Development, Affecting Psychiatric-Relevant Behaviors
A new study identifies mitogen- and stress-activated kinase 1 (MSK1) as a key mediator in brain-derived neurotrophic factor (BDNF) pathways critical.
Cerebellar iTBS Improves Post-Stroke Cognition via Dentate Nucleus-Ventromedial Thalamus Pathway
A mouse model study identifies the specific neural circuit mediating the cognitive benefits of intermittent theta-burst stimulation after stroke.
Stag2 Deficiency Reprograms GATA1 Binding, Driving Dyserythropoiesis in Myelodysplastic Syndromes
Loss of Stag2 alters chromatin accessibility, redirecting GATA1's transcriptional activity from erythroid to megakaryocyte pathways.