Platelet Transfusion Linked to Higher Mortality in Sepsis Patients
A retrospective study finds transfusions increase ICU stay and thrombosis risk while failing to raise counts in half of septic patients.
Psychological Factors Predict High-Impact Chronic Pain in Sickle Cell Disease
A prospective study of 90 patients shows that pain catastrophizing and low self-efficacy correlate with sustained functional impairment.
Awake Mapping for Grade 2 Glioma Reduces Intractable Epilepsy Burden
Extensive resection of IDH-mutant tumors improves seizure freedom and return-to-work rates, particularly for insular lesions.
Prenatal SRI Exposure Linked to Altered Fetal Brain and Placental Growth
MRI data show reduced hippocampal volume and cortical folding in fetuses exposed to antidepressants or high maternal depression scores.
Taekwondo and Football 5-a-Side Show Highest Injury Risk at Paris Paralympics
Prospective surveillance of 4,450 athletes reveals significant sex-based and sport-specific variations in injury burden and illness rates.
Freezing of Gait Linked to Maladaptive Task Prioritization in Parkinson’s
Patients with freezing of gait maintain walking speed by sacrificing manual task accuracy, driven by impaired theta-band neural activity.
Iron and Lead Levels Linked to Brain Microstructure in Autistic Language Delay
Low serum iron and high lead levels correlate with reduced neurite complexity in language-processing regions of children with autism.
Standard Weight Formulas Overestimate Lung Size in Critically Ill Women
A large-scale analysis reveals that current tidal volume guidelines increase driving pressures and mortality risk for female patients.
Apathy Mechanisms Differ Between Alzheimer's and Parkinson's Disease
Computational modeling reveals distinct effort-sensitivity profiles and neural signatures for motivational loss across neurodegenerative types.
SPAST Variant Mapping Predicts Disease Trajectory in Spastic Paraplegia Type 4
Genetic essentiality mapping and neurofilament levels differentiate rapid functional decline from moderate biphasic progression in SPG4.
Patient Position Alters Quantitative CT Measurements of Interstitial Lung Abnormalities
Supine and prone CT scans show significant variability in lung abnormality quantification, particularly in nonfibrotic components.
Medial Temporal Lesions Impair Memory Precision Rather Than Capacity
Post-surgical data from 40 epilepsy patients show hippocampal damage increases recall variability without reducing the total items retained.