Sleep Efficiency Improvements Drive Antidepressant Response to CBT for Insomnia
A mechanistic trial shows that objective sleep gains, not changes in brain emotional circuits, correlate with improved mood symptoms.
Nucleus Accumbens Dopamine Regulates Multi-Option Foraging Rates in Mice
A global learning rate in the nucleus accumbens core allows for rapid value integration across six concurrent choices in large arenas.
Penetrating Brain Injury Mortality Reaches 42% While Prophylaxis Compliance Lags
Despite high mortality, 70% of survivors achieve favorable outcomes, though adherence to antibiotic and seizure protocols remains low.
Tirofiban Improves 90-Day Outcomes After Inadequate Tenecteplase Response
Adjunctive tirofiban increased the rate of functional independence in patients with non-large vessel stroke who failed to improve.
SMART Model Matches Radiologists in Differentiating New Lung Malignancies
A CT-based tool using semantic features like emphysema and spiculation helps distinguish second primary lung cancers from metastases.
Chronic Stroke Survivors Retain Motivational Drive Despite Impaired Reward Learning
A study of 40 patients shows that while stroke slows belief updating, the ability to speed up movements for rewards remains intact.
SSPOP Gene Mutations Linked to Pediatric Epilepsy and Developmental Delay
Researchers identify pathogenic variants in a presumed pseudogene, expanding the diagnostic landscape for unexplained seizure disorders.
Prostate SBRT Maintains 90% Relapse-Free Survival at Ten Years
A multi-center trial of 310 patients shows low- and intermediate-risk prostate cancer control remains durable with minimal late toxicity.
CT Metrics Predict Benralizumab Response in Severe Asthma
Quantitative imaging of small airway disease and sinus opacification identifies responders more accurately than blood eosinophil counts.
Magnetic Seizure Therapy Limits Memory Loss in Bipolar Depression Trial
A randomized pilot study shows magnetic seizure therapy matches the efficacy of ultrabrief ECT while reducing cognitive adverse effects.
Microsurgical Breast Reconstruction Remains Undervalued Despite Improved Efficiency
A 13-year analysis reveals that while free flap reimbursement per hour has risen, it still lags significantly behind implant-based options.
Skin Biopsies Differentiate Body-First and Brain-First Parkinson’s Disease
Cutaneous alpha-synuclein patterns and seeding kinetics identify distinct pathological origins in Parkinson’s disease subtypes.