NXT007 Reaches Nonhemophilic Factor VIII Levels in Severe Hemophilia A
A phase 1/2 trial shows monthly subcutaneous NXT007 achieves factor activity above 40 IU/dL and eliminates bleeds at higher doses.
Carotid Doppler Parameters Predict Return of Spontaneous Circulation During CPR
Waveform-derived metrics like velocity time integral show high predictive value for resuscitation success in emergency department patients.
Locomotion Selectively Suppresses Hippocampal Pyramidal Cell Bursting in Mice
All-optical electrophysiology reveals that balanced excitatory and inhibitory inputs modulate gain in CA1 neurons during physical activity.
Photon-Counting CT Improves Pulmonary Artery Visibility at Lower Radiation Doses
Ultra-high-resolution imaging increases diagnostic confidence and vascular attenuation compared to standard energy-integrating detectors.
Selective HDAC6 Inhibition Restores Axonal Transport in Preclinical ALS Models
A brain-penetrant small molecule improves motor function and reduces TDP-43 pathology in animal and human cellular models of neurodegeneration.
Amygdala Damage Does Not Impair Intrinsic Motivation to Empathize
Patients with focal amygdala lesions maintain a normal drive to engage in empathic encounters despite deficits in emotional recognition.
THC Disrupts Rat Fear Memory via Sex-Specific Microglial and Receptor Pathways
In male rats, THC requires microglial recruitment and dual receptor signaling, while female effects depend on the estrous cycle and CB1.
Gamma Knife Surgery Provides Durable Control of Vestibular Schwannoma
A 30-year study shows true tumor progression is rare after 10 years, supporting reduced imaging for patients stable at the 5-year mark.
Child Maltreatment Linked to Systemic Homeostatic Dysregulation
Recent trauma in children may disrupt physiological stability and delay development in males rather than accelerating biological aging.
Propofol Reduces Long-Term Water Contamination Compared to Sevoflurane
A modeling study finds sevoflurane leads to irreversible accumulation of trifluoroacetic acid while propofol residues remain biodegradable.
Lumateperone Leads Efficacy While Aripiprazole Shows Best Acceptability in Depression
A meta-analysis of 10,962 patients quantifies the trade-offs between symptom reduction and treatment adherence for adjunctive antipsychotics.
BRAF V600E Mutation Predicts Early Recurrence in Rathke Cleft Cysts
A retrospective analysis of 383 sellar lesions suggests BRAF-positive cysts behave like papillary craniopharyngiomas and require reclassification.