Bispecific CAR T-Cells Show High Response in Extramedullary Multiple Myeloma
A phase 2 trial reports high overall response and manageable safety with anti-BCMA/GPRC5D CAR T-cells for relapsed/refractory disease.
Imdusiran Demonstrates Favorable Safety Profile in Early Hepatitis B Trial
A phase 1a/b study of the siRNA imdusiran shows it is well tolerated in healthy individuals and chronic hepatitis B patients.
CBD's Pain Modulation Effects Vary by Opioid Dosing Timing in OUD Patients
A crossover study reveals cannabidiol's impact on pain sensitivity is dependent on whether opioid agonist treatment has been administered.
ITBS Improves Fibromyalgia Symptoms; D-Cycloserine Augments Depressive Symptoms Only
A randomized trial found intermittent theta-burst stimulation significantly reduced fibromyalgia symptoms, but adjunctive D-Cycloserine only…
GIP Infusion Does Not Improve Glycemic Control in Type 2 Diabetes
A 6-week subcutaneous GIP infusion, alone or with semaglutide, did not meet its primary glycemic target in patients with type 2 diabetes.
Cryoprobe Improves Diagnostic Yield in Transbronchial Lung Biopsy
A multicenter randomized trial finds 1.1-mm cryoprobes provide higher diagnostic yield than 2.0-mm forceps for lung biopsies.
ABCDEF Bundle Does Not Reduce Delirium, Improves Specific Quality of Life Domain
A randomized trial in Australian ICU patients found no delirium reduction with the ABCDEF bundle, but noted better 90-day 'usual activities' scores.
Low-Dose Buprenorphine Sustains Ketamine's Antisuicidal Effects in MDD
A randomized trial indicates sublingual buprenorphine extends ketamine's rapid reduction of suicidal ideation in major depressive disorder.
MIPD Improves Early Postoperative Activity, Reduces Stress for Pancreatic Resection
A randomized trial shows minimally invasive pancreatoduodenectomy leads to higher physical activity and heart rate variability for weeks.
IL-6 Inhibition Shows Clinical Signals in Refractory Depression
A small trial of tocilizumab for difficult-to-treat depression suggests potential for symptom improvement and identifies patient selection markers.
Weight Loss Intervention Safe in Older AF Patients, But Does Not Improve Symptoms
A randomized clinical trial indicates that while weight loss is achievable and safe in older, overweight AF patients, it may not reduce AF symptoms.
Azithromycin Does Not Reduce Acute Wheezing Severity in Preschoolers
A multicenter trial found azithromycin offered no significant clinical benefit over placebo for moderate-to-severe wheezing symptoms.