The Briefing · Emergency & Critical Care
Continuous newsroom coverage of evidence in Emergency & Critical Care — newest first.
LEAD STORY
IV Iron Linked to Improved Survival, Anemia Recovery in Acute Infection
A retrospective cohort study suggests intravenous iron administration during acute infection does not worsen outcomes and may offer benefits.
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Itraconazole Inhibits OXPHOS in AML, Targets Therapy-Resistant Leukemic Stem Cells
A drug-repurposing screen identifies the antifungal itraconazole as an oxidative phosphorylation inhibitor effective against AML leukemic stem cells.
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Orca-T Immunotherapy Enriches Regulatory-Like T-Cells Early Post-Transplant
A specific T-cell subset, CD4+CD25-FOXP3+Helios+ T conventional cells, is enriched early after Orca-T and correlates with later immune activation.
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IL-1β Signaling Drives Aggressive TCF3::HLF B-ALL and Bone Lesions
A new study identifies interleukin-1β as a key driver in a highly aggressive B-cell acute lymphoblastic leukemia subtype.
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TTP: EEG Delta Activity Correlates With Transient Aphasia, Resolves With Treatment
A case report details how left temporal lateralized rhythmic delta activity (LRDA) on EEG tracked fluctuating aphasia in TTP, resolving with targeted
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QCT Fibrosis Score Thresholds Predict Transplant-Free Survival in IPF
Specific quantitative CT fibrosis score changes identify idiopathic pulmonary fibrosis patients at higher risk for worse outcomes.
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Naloxone Linked to Improved Survival in PEA Out-of-Hospital Cardiac Arrest
A retrospective cohort study suggests prehospital naloxone administration is associated with better survival to discharge for OHCA patients.
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Prone Positioning Use Surged During Pandemic, Declined Post-COVID
A North American study reveals a significant increase in prone positioning for hypoxemic patients during the pandemic, followed by a notable decrease.
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AL Amyloidosis Prognostic Models Lag Behind Treatment Advances
Current risk stratification tools for AL amyloidosis do not reflect improved patient outcomes with modern daratumumab-based regimens.
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Neurobehavioral Profile of Young Steroid-Naive Boys With Duchenne Muscular Dystrophy
A multinational study characterizes baseline social, emotional, and learning challenges in young boys with Duchenne muscular dystrophy.
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EXCC Device Shows Safety, Efficacy for Angulated Aortic Necks at One Year
A Japanese multicenter registry reports one-year outcomes for the Gore Excluder Conformable device in patients with challenging proximal aortic.
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Key Factors Drive Tidal Recruitment/Derecruitment in Spontaneously Breathing ARDS
A study identifies specific physiological and radiological determinants of lung injury in ARDS patients on pressure support ventilation.
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Proximity-Based Lung Allocation Policy May Worsen Geographic Disparities
A new study suggests that increasing donor-candidate proximity in lung allocation could reduce donor availability and disadvantage harder-to-match.
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ECMO Escalation in ARDS: Prevalence, Mortality, and Hospital Volume Impact
A large Chinese cohort study details the incidence and outcomes of venovenous ECMO escalation in ARDS, highlighting mortality risks.
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Autoimmune Encephalitis Subtypes Identified in Rapidly Progressive Dementia
A multicenter study clarifies the prevalence and clinical presentations of specific autoimmune encephalitis subtypes in patients with rapidly progress
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Initial Central Venous Puncture Reduces Blood Culture Contamination
Sampling blood cultures before central line insertion significantly lowers contamination rates without compromising pathogen detection.
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Bispecific CAR T-Cells Show High Response in Extramedullary Multiple Myeloma
A phase 2 trial reports high overall response and manageable safety with anti-BCMA/GPRC5D CAR T-cells for relapsed/refractory disease.
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Early Bradycardia Predicts Need for Positive Pressure Ventilation in Newborns
An observational study quantifies heart rate response to tactile stimulation and identifies early bradycardia as a marker for advanced resuscitation.
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Double Sequential Defibrillation Implementation Shows No Survival Benefit in New Zealand EMS
A retrospective cohort study found no improvement in return of spontaneous circulation or 30-day survival after DSD introduction.
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Bicarbonate Reduces Renal Replacement Therapy in Critically Ill Adults
A meta-analysis of four randomized controlled trials indicates sodium bicarbonate significantly lowers the need for renal replacement therapy.
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Sickle Cell Trait Not Linked to Overall Mortality or Cardiovascular Disease
A large UK Biobank study finds sickle cell trait does not increase all-cause death or cardiovascular events, but associates with diabetes, kidney…