Maternal Microbial Exposure Confers Intergenerational Stress Resilience in Male Mouse Offspring
Maternal administration of a heat-killed bacterium protected male offspring from chronic stress effects, potentially via microbiome changes.
White Matter Microstructure Changes May Reflect Active Illness, Not Just Familial Risk
A large meta-analysis suggests that white matter abnormalities in schizophrenia and bipolar disorder are more tied to the disease process…
Widespread Cortical Alterations in Adolescent Early-Onset Psychosis
A large-scale mega-analysis reveals extensive structural brain differences in adolescents with early-onset psychosis compared to controls.
MSK1 Mediates BDNF Signaling in Striatal Development, Affecting Psychiatric-Relevant Behaviors
A new study identifies mitogen- and stress-activated kinase 1 (MSK1) as a key mediator in brain-derived neurotrophic factor (BDNF) pathways critical.
TMEM106B Variant Delays FTD Onset in GRN Mutation Carriers
A specific genetic variant significantly reduces FTD onset risk and extends median onset age by 14 years in GRN mutation carriers.
Social Rank Modulates Empathic Pain via ACC-NAcC Circuit in Mice
A specific glutamatergic pathway and molecular target influence empathic pain responses based on social hierarchy.
SSRIs Induce Spatially Distinct Molecular Changes in Dorsal Raphe Serotonin Neurons
A mouse study reveals how fluoxetine alters gene expression and neuropeptide levels in specific serotonergic subpopulations.
Postpartum Psychosis Heritability Estimated, Specific Risk Genes Identified
New research quantifies genetic contributions to postpartum psychosis and identifies specific genes, including shared pathways with other psychiatric
Apelin Mediates Exercise's Antidepressant Effects via Hippocampal NMDA Receptors
A muscle-derived protein, apelin, links physical activity to improved mood and neuroplasticity through a specific brain signaling pathway.
Thalamic Connections to Medial Prefrontal Cortex Predict Impulsivity
A new study links specific thalamic subregions, defined by cortical connectivity, to individual differences in delay discounting.
Thalamic-MPFC Connectivity Linked to Individual Differences in Impulsivity
A new study identifies specific thalamic subregions connected to the medial prefrontal cortex as structural correlates of delay discounting.
Nitrous Oxide Addiction Linked to DCN-VTA Circuit, AMPA Receptor Potentiation
A new study identifies how nitrous oxide directly enhances AMPA receptor function in the DCN-VTA circuit, mediating its rewarding effects.