Trial Watch
Clinical trials covered by The Clinical Lighthouse, ranked by methodological rigor and ordered by most recent.
Prehospital Whole Blood Does Not Reduce 30-Day Mortality Over Components
A large-scale trial found no significant difference in 30-day mortality between prehospital whole blood and component transfusions for trauma.
Randomized Controlled Trial
Bispecific CAR T-Cells Show High Response in Extramedullary Multiple Myeloma
A phase 2 trial reports high overall response and manageable safety with anti-BCMA/GPRC5D CAR T-cells for relapsed/refractory disease.
Randomized Controlled Trial
Imdusiran Demonstrates Favorable Safety Profile in Early Hepatitis B Trial
A phase 1a/b study of the siRNA imdusiran shows it is well tolerated in healthy individuals and chronic hepatitis B patients.
Randomized Controlled Trial
CBD's Pain Modulation Effects Vary by Opioid Dosing Timing in OUD Patients
A crossover study reveals cannabidiol's impact on pain sensitivity is dependent on whether opioid agonist treatment has been administered.
Randomized Controlled Trial
ITBS Improves Fibromyalgia Symptoms; D-Cycloserine Augments Depressive Symptoms Only
A randomized trial found intermittent theta-burst stimulation significantly reduced fibromyalgia symptoms, but adjunctive D-Cycloserine only…
Randomized Controlled Trial
GIP Infusion Does Not Improve Glycemic Control in Type 2 Diabetes
A 6-week subcutaneous GIP infusion, alone or with semaglutide, did not meet its primary glycemic target in patients with type 2 diabetes.
Non-Randomized Controlled Trial
Venetoclax Plus Chemotherapy Improves MRD Response, Survival in Ph-Negative ALL
A phase 2 study shows venetoclax combined with pediatric-inspired chemotherapy enhances outcomes for newly diagnosed adolescents and adults.
Randomized Controlled Trial
Cryoprobe Improves Diagnostic Yield in Transbronchial Lung Biopsy
A multicenter randomized trial finds 1.1-mm cryoprobes provide higher diagnostic yield than 2.0-mm forceps for lung biopsies.
Randomized Controlled Trial
ABCDEF Bundle Does Not Reduce Delirium, Improves Specific Quality of Life Domain
A randomized trial in Australian ICU patients found no delirium reduction with the ABCDEF bundle, but noted better 90-day 'usual activities' scores.
Non-Randomized Controlled Trial
AI 3D Morphing Reduces Revisions, Improves Outcomes in African American Rhinoplasty
A study of 392 patients found AI 3D morphing in rhinoplasty led to fewer revisions and better aesthetic and psychosocial scores.
Randomized Controlled Trial
Low-Dose Buprenorphine Sustains Ketamine's Antisuicidal Effects in MDD
A randomized trial indicates sublingual buprenorphine extends ketamine's rapid reduction of suicidal ideation in major depressive disorder.
Randomized Controlled Trial
MIPD Improves Early Postoperative Activity, Reduces Stress for Pancreatic Resection
A randomized trial shows minimally invasive pancreatoduodenectomy leads to higher physical activity and heart rate variability for weeks.
Randomized Controlled Trial
IL-6 Inhibition Shows Clinical Signals in Refractory Depression
A small trial of tocilizumab for difficult-to-treat depression suggests potential for symptom improvement and identifies patient selection markers.
Randomized Controlled Trial
Azithromycin Does Not Reduce Acute Wheezing Severity in Preschoolers
A multicenter trial found azithromycin offered no significant clinical benefit over placebo for moderate-to-severe wheezing symptoms.
Randomized Controlled Trial
Weight Loss Intervention Safe in Older AF Patients, But Does Not Improve Symptoms
A randomized clinical trial indicates that while weight loss is achievable and safe in older, overweight AF patients, it may not reduce AF symptoms.
Randomized Controlled Trial
Inhaled Treprostinil Slows Lung Function Decline, Reduces Clinical Worsening in IPF
A phase 3 trial demonstrates that inhaled treprostinil significantly mitigates FVC reduction and clinical deterioration in patients with idiopathic.
Randomized Controlled Trial
4% Tetrasodium EDTA Lock Reduces CVAD Complications in ICU Adults
A multicenter, cluster-randomized trial shows 4% t-EDTA locking fluid decreases a composite of CVAD-associated events, primarily catheter occlusions.
Randomized Controlled Trial
Tezepelumab Reduces Oral Corticosteroid Use in Severe Asthma
A phase 3 trial demonstrates that tezepelumab significantly lowers daily oral corticosteroid dose in adults with severe, OCS-dependent asthma.
Randomized Controlled Trial
Amitriptyline Not Superior to Placebo for Leprosy-Related Neuropathic Pain
A randomized controlled trial found amitriptyline did not offer additional analgesia as add-on therapy for neuropathic pain in leprosy.
Randomized Controlled Trial
Selective Early PDA Pharmacotherapy Feasible in Extremely Preterm Infants
A pilot randomized trial demonstrates the feasibility of a targeted medical approach for patent ductus arteriosus in infants under 26 weeks'.
Randomized Controlled Trial
New Tool Assesses Integrative Oncology Competencies in Trainees
A validated questionnaire helps evaluate baseline clinical skills in integrative oncology among healthcare provider trainees, supporting targeted.
Randomized Controlled Trial
Remote Multicomponent Rehabilitation Does Not Improve Quality of Life for ICU Survivors
A randomized trial found a 6-week remote rehabilitation program did not significantly enhance health-related quality of life at 8 weeks.
Randomized Controlled Trial
AD109 Reduces Apnea-Hypopnea Index in PAP-Intolerant OSA Patients
An oral combination of aroxybutynin and atomoxetine significantly improved objective respiratory metrics over 26 weeks.
Randomized Controlled Trial
Astegolimab Reduces COPD Exacerbations in Broad Patient Population
A pooled analysis of two trials shows astegolimab significantly lowers moderate/severe exacerbation rates in patients with frequent COPD.
Randomized Controlled Trial
Armchair Positioning Improves Oxygenation in Spontaneously Breathing ICU Patients
A randomized controlled trial found out-of-bed armchair positioning increased PaO2/FiO2 ratios compared to in-bed semi-recumbent positioning.
Randomized Controlled Trial
Tea Polyphenols Mitigate Brain Changes, Anxiety in Aged Diabetic Rats
A preclinical study in aged T2DM rats suggests tea polyphenol intervention may improve hippocampal structure, function, and behavior.
Randomized Controlled Trial
Digital Decision Aid Boosts STI Testing in ED for Young Adults
A randomized trial shows a smartphone-based tool significantly increases gonorrhea/chlamydia and pharyngeal STI testing rates in emergency department
Non-Randomized Controlled Trial
Sternal Vibration Plus Mindfulness Improves Body Awareness, White Matter in Trauma
A study in trauma-exposed adults found sternal vibration combined with mindfulness meditation enhanced interoceptive awareness and increased neurite.
Randomized Controlled Trial
Anti-C5a Antibody STSA-1002 Shows Favorable Safety, Reduced Mortality in ARDS
A phase 1b/2 trial indicates STSA-1002 is well tolerated and associated with lower 28-day mortality in viral pneumonia-induced ARDS.
Randomized Controlled Trial
CTBS to Right DLPFC Reduces Heavy Drinking Relapse Risk in AUD Over 12 Months
Continuous theta-burst stimulation to the right DLPFC lowered heavy-drinking relapse risk in AUD over 12 months in a randomized trial.