The Briefing
Continuous newsroom coverage of clinically relevant evidence — newest first.
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Dual PH-Targeted Therapy Reduces BPA Complications, Improves Outcomes in CTEPH
A Dutch registry study indicates that dual pulmonary hypertension-targeted medical pretreatment lowers periprocedural risks and enhances clinical bene
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Teriparatide Plus Zoledronic Acid Does Not Reduce Fracture Risk in Adults with OI
A randomized trial found that while combination therapy increased bone mineral density, it did not lower fracture incidence.
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Macaque V1 Neuron Activity Links Internal States to Reaction Time, Perceptual Choice
New research in macaque monkeys reveals how primary visual cortex neuron membrane potential dynamically influences visual task performance.
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Familial Brain Pattern Similarity Links to Psychotic Disorder Risk in Offspring
A new index quantifying cortical thickness similarity between parents with psychosis and their offspring correlates with psychiatric diagnoses.
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Acute Kidney Injury Predicts Increased Risk of Stroke and Dementia
A meta-analysis of 11 million patients links acute renal insults to a 35% higher stroke risk and nearly fivefold 90-day poststroke mortality.
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Circulating Tumor DNA Predicts Progression-Free Survival in Hodgkin Lymphoma
A validated sequencing assay identifies patients at high risk for relapse after two cycles of chemotherapy in the GHSG HD21 trial.
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Intracranial Recordings Map Immediate and Distal Neural Responses to Magnetic Stimulation
A review of human and primate data shows single-pulse TMS excites neurons in 2 milliseconds and modulates networks for up to 40 minutes.
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Digital Interventions Improve Eating Disorder Symptoms and Comorbid Mental Health
A meta-analysis of 36 trials shows digital tools offer consistent, durable benefits for core eating disorder symptoms and associated mental health con
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Maternal Genetic Variants Linked to Aneuploid Conception Identified in Review
A systematic review identifies specific maternal genetic variants associated with aneuploid conceptions, offering new insights for infertility diagnos
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CMR and NT-proBNP Improve Risk Prediction in Hypertrophic Cardiomyopathy
A prospective registry study identifies myocardial scar and natriuretic peptide levels as key predictors of long-term adverse outcomes.
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Memory Deficits Persist in Multiple Sclerosis Despite Preserved Processing Speed
Modern treatment eras show a shift where cognitive slowing is no longer the primary deficit in relapsing-remitting multiple sclerosis.
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Current Late-Life Depression Linked to Specific Right Hippocampal Subregion Volume Reductions
A new study details distinct hippocampal volume alterations in currently depressed older adults, differentiating them from remitted states.
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Patient-Level Adherence Drives Enhanced Recovery Benefits in Pediatric GI Surgery
A stepped-wedge trial shows that while site-level ERP implementation may not reduce length of stay, patient-level adherence does.
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REM Sleep EEG Slowing Linked to Cholinergic Denervation in Older Adults
Specific REM sleep electroencephalogram patterns correlate with brain cholinergic integrity, potentially aiding early diagnosis in Alzheimer's disease
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Bone Marrow Iron Predicts Mortality in Cirrhosis with Normal Liver Iron
Vertebral R2* relaxometry identifies a high-risk subgroup of patients with cirrhosis facing a fourfold increase in five-year mortality.
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Aerobic, Combined, and HIIT Exercise Lower Ambulatory Blood Pressure in Hypertension
A network meta-analysis clarifies the impact of various exercise types on 24-hour blood pressure in adults with hypertension.
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Maternal Fasting in Mice Induces Schizophrenia-Related Phenotypes
A mouse model links transient fasting during early gestation to epigenetic changes and altered neural circuitry in offspring.
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Focal Brain Lesions Pinpoint Common OCD Network and Treatment Targets
A systematic review identifies a shared brain network in lesional and primary OCD, aligning with neuroimaging and neuromodulation sites.
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Cryoablation Reduces Umbilical Endometriosis Pain and Volume in Outpatient Study
Percutaneous image-guided cryoablation achieved 82% complete pain relief and 73% volume reduction for umbilical endometriosis.
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High Antiplatelet Resistance, Elevated von Willebrand Factor in Vascular Surgery Patients
A new study reveals a high prevalence of antiplatelet resistance, particularly to clopidogrel, and elevated von Willebrand factor in patients undergoi
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Habenula Hyperconnectivity in Autism Linked to Social Deficits
A large-scale rs-fMRI study identifies specific habenula functional connectivity alterations in autistic individuals, impacting social motivation.
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Age, Sex, and Initial Diagnosis Shape Mental Disorder Trajectories
A large Danish cohort study details how initial diagnosis, age, and sex influence diagnostic shifts and healthcare utilization.
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Lower Oxygen Saturation Target Reduces Pediatric Hospital Stay, Oxygen Therapy
A multicenter trial suggests targeting 88% peripheral oxygen saturation in children with acute respiratory illness shortens hospitalizations.
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Percutaneous Cryoablation Reduces Pain and Volume in Umbilical Endometriosis
A retrospective study of 17 patients shows high satisfaction and significant symptom relief with an outpatient interventional approach.