The Briefing
Continuous newsroom coverage of clinically relevant evidence — newest first.
Earlier
24 stories-
Hippocampal Lesions Reduce Visual Working Memory Precision in Epilepsy Patients
Postoperative hippocampal damage selectively degrades memory quality rather than quantity, offering a marker for functional monitoring.
-
Extra-Pulmonary TB Linked to Persistent Lung Function Deficits
A new study reveals that extra-pulmonary tuberculosis survivors experience lasting respiratory impairment, similar to pulmonary TB.
-
Extrapulmonary TB Linked to Persistent Lung Function Deficits, Respiratory Symptoms
A new study reveals that individuals treated for extrapulmonary tuberculosis frequently develop lasting ventilatory defects and respiratory symptoms.
-
Sutureless Robotic Partial Nephrectomy Noninferior to Renorrhaphy for Renal Tumors
A randomized controlled trial indicates sutureless off-clamp robotic partial nephrectomy offers comparable surgical quality for cT1-2N0M0 renal tumors
-
Reduced ULK1 Links Impaired Cellular Clearance to Alzheimer's Pathology
Lower levels of ULK1 correlate with Alzheimer's disease, and its upregulation improves pathology and cognition in animal models.
-
Thalamic Connections to Medial Prefrontal Cortex Predict Impulsivity
A new study links specific thalamic subregions, defined by cortical connectivity, to individual differences in delay discounting.
-
Thalamic-MPFC Connectivity Linked to Individual Differences in Impulsivity
A new study identifies specific thalamic subregions connected to the medial prefrontal cortex as structural correlates of delay discounting.
-
CCL19 Tracks IgG4-Related Disease Activity, Supplements IgG4 Levels
A new study identifies C-C motif chemokine ligand 19 as a dynamic serum biomarker for monitoring IgG4-RD treatment response and relapse.
-
ECPR for OHCA in Singapore: Cost-Effective, but Sensitive to Transport Delays
A simulation-based analysis suggests ECPR for refractory OHCA in Singapore is cost-effective, though transport time significantly impacts its economic
-
Telitacicept Reduces Proteinuria in IgA Nephropathy: Phase 3 Interim Analysis
A dual BAFF and APRIL antagonist significantly lowers urinary protein-to-creatinine ratio in adults with IgA nephropathy at high risk of progression.
-
Prefrontal GABAergic Synaptic Plasticity Regulates Cognitive Flexibility
A new study identifies a specific long-range inhibitory synaptic mechanism in the prefrontal cortex crucial for adapting to changing rules.
-
Brepocitinib 30 mg Improves Dermatomyositis Symptoms and Reduces Glucocorticoid Need
A phase 3 trial shows that once-daily oral brepocitinib 30 mg significantly improves disease activity and allows for glucocorticoid tapering in adults
-
Nitrous Oxide Addiction Linked to DCN-VTA Circuit, AMPA Receptor Potentiation
A new study identifies how nitrous oxide directly enhances AMPA receptor function in the DCN-VTA circuit, mediating its rewarding effects.
-
Nitrous Oxide Reward Driven by DCN-VTA Circuit, AMPA Receptor Potentiation
A new study in animal models identifies the specific neural circuit and molecular mechanism underlying nitrous oxide's rewarding effects.
-
IDH1 Mutations in Prostate Cancer Link High Stage/Grade to Favorable Outcomes
A retrospective analysis identifies IDH1 mutations as a marker for improved survival in prostate cancer, despite aggressive initial presentation.
-
CPES Score May Better Identify PE Patients Needing Advanced Intervention
A retrospective study suggests the Composite Pulmonary Embolism Shock score offers improved prediction for advanced interventions in PE.
-
CPES Score Identifies PE Patients Needing Advanced Intervention
A retrospective study finds the Composite Pulmonary Embolism Shock score particularly effective in predicting the need for advanced therapies.
-
Urinary Nanoprobe Detects Therapy-Induced Senescence in Lung Cancer, Fibrosis
A new injectable albumin-based nanoprobe allows noninvasive, longitudinal monitoring of cellular senescence burden via urine testing.
-
GABAergic Signaling and SST Interneurons Boost Dendritic Calcium Influx
A new study in mice reveals how specific GABA-A receptors and somatostatin-expressing interneurons can paradoxically enhance neuronal calcium signalin
-
PsA Improvement Thresholds Vary by Baseline Disease Activity, Not Prior TNFi Exposure
Minimal clinically important improvement (MCII) thresholds in psoriatic arthritis depend on baseline disease severity, guiding personalized treatment.
-
Parkinson's Dementia Risk Lower, Later Than Prior Estimates
New data from the Parkinson's Progression Markers Initiative refines understanding of cognitive decline prevalence and progression.
-
UK and Ireland Neonatal Stroke Incidence: 9.0 per 100,000 Live Births
A new surveillance study details the epidemiology, clinical patterns, and short-term outcomes of neonatal stroke in the UK and Ireland.
-
UK Neonatal Stroke Incidence: 9.0 per 100,000 Live Births, Varied Presentations
A new surveillance study details the incidence, clinical features, and initial management of neonatal stroke in the UK and Ireland.
-
Dual PH Therapy Before BPA Reduces Complications, Improves Outcomes in CTEPH
A Dutch registry study indicates that dual pulmonary hypertension-targeted medical therapy improves safety and efficacy of balloon pulmonary angioplas