Brain Connectivity Predicts Escitalopram Response in Depressed Adolescents
Specific resting-state functional connectivity patterns may identify adolescents with major depressive disorder who will respond to escitalopram.
Consensus Checklist and Passing Standard for Brain Death Competency
A Delphi and Angoff process established a 98-item checklist and an 89% minimum passing score for BD/DNC determination.
Germline Variants Linked to Increased Cancer Risk in Pediatric Patients
A large-scale analysis of pediatric exome sequencing data reveals specific germline variants significantly elevate future cancer incidence.
Retrosplenial Cortex Adapts History Integration for Flexible Decisions
Mouse study reveals how the retrosplenial cortex dynamically adjusts its processing of past experiences to support adaptive behavior.
Delayed Awakening After Cardiac Arrest: Prognostic Implications and Recovery Potential
A scoping review highlights variable definitions and the potential for good neurological recovery despite delayed awakening after OHCA.
ESS More Cost-Efficient Than Biologics for CRSwNP in Spanish NHS
A 10-year economic analysis finds endoscopic sinus surgery offers better value than biologics for chronic rhinosinusitis with nasal polyps.
Brain-Wide Index Identifies Youth at Risk for Bipolar Disorder
A new study links a structural brain marker, the Regional Vulnerability Index for Bipolar Disorder, to familial risk and early symptoms.
Expert Consensus Guides 1.1 mm Cryoprobe Use in Non-ILD Transbronchial Biopsy
An international Delphi panel established 31 consensus statements for transbronchial cryobiopsy in non-interstitial lung disease.
Population Screening Identifies Early Type 1 Diabetes in Children, Quantifies Progression
A large-scale study in Bavaria, Germany, reveals the prevalence and progression rates of presymptomatic type 1 diabetes in a general pediatric…
Foamy Microglia and Lipid Metabolism Link to Multiple Sclerosis Lesion Expansion
A distinct microglial subtype and altered lipid pathways drive lesion progression in secondary progressive MS, suggesting new therapeutic avenues.
Higher Rocuronium Dose Linked to Increased First-Attempt Intubation Success in ICU
A secondary analysis suggests that rocuronium doses above 1.2 mg/kg improve intubation success in critically ill ICU patients.
Red Blood Cells Contribute Alpha-Synuclein to Parkinson's Brain Pathology
A new study in human tissues and mouse models identifies erythrocytes as a peripheral source of alpha-synuclein, influencing central nervous system.