Adolescent Nicotine Rewires Brain Circuitry to Boost Opioid Reward in Mice
Early nicotine exposure alters GABA signaling in the ventral tegmental area, amplifying the rewarding effects of morphine in adult mice.
Dopamine Blockade Attenuates Morphine Analgesia in Rat Hippocampus
Blocking D1 dopamine receptors in the dentate gyrus significantly reduces the pain-relieving effects of morphine in an animal model.
Hippocampus-Thalamus Circuit Drives Contextual Hyperactivity in PTSD Mouse Model
A specific glutamatergic pathway may be a therapeutic target for context-dependent arousal symptoms.
Nicotine Rewires Habenular Circuits in Mice, Altering Food Motivation
Chronic nicotine exposure in mice disrupts top-down control of the LDT-VTA cholinergic axis, driving exaggerated food-seeking behavior.
Vitamin C Reverses Depression-Like Behavior in Female Mice via D2 Receptors
A single dose of ascorbic acid restored dopamine D2 receptor signaling in the prefrontal cortex, rapidly alleviating depression in mice.
Inhibiting RhoA in Rat Prefrontal Cortex Reduces Morphine Dependence
Blocking the RhoA pathway in rats reduces opioid-induced neuroplasticity and limits glutamate spillover, offering a specific addiction target.
Epigenetic Target HDAC5 Reduces Environment-Triggered Cocaine Seeking in Rats
In a rat model, overexpressing the enzyme HDAC5 in the prelimbic cortex shifted synaptic balance to suppress context-driven cocaine seeking.
NMDA Receptor Ablation in Adolescent Mice Triggers Synaptic Rebound
Removing NMDA receptors in the adolescent mouse prefrontal cortex causes an initial spine loss followed by a compensatory synaptic rebound.